Risperidone (Adverse effects)

Risperidone is an atypical neuroleptic of an effectiveness similar to that of other highly potent neuroleptics. It acts by modifying certain natural substances in the brain.

Risperidone is a medication that is used to treat positive persistent symptoms of schizophrenia (a mental disorder that causes disturbed or unusual thinking, a disinterest in life and strong or inappropriate emotions). It is used as well to treat episodes of mania (euphoric state of mind, abnormally enthusiastic or irritated) or mixed episodes (symptoms of mania and depression occurring together).

Risperidone is also prescribed to treat behavioral problems such as aggressiveness, self-injury and abrupt mood changes in autistic children and adolescents between the ages of 5 – 16.


  • Arketin®
  • Diaforin®
  • Rispemylan®
  • Risperdal®
  • Risperidona®


The side effects associated with risperidone are:

  • Insomnia
  • Agitation
  • Anxiety
  • Headache and extrapyramidal effects
  • Weight gain (2.7 kg/year)
  • Occasional hyperglycemia
  • Increased risk of acute cerebrovascular accident (ACVA) in patients over 65 years of age with behavioral disorder or psychosis associated with dementia (the risk/benefit effects should be carefully weighed)
  • Cardiovascular risk is significantly higher in patients with mixed type or vascular dementia than in Alzheimer-type dementia.

Less frequent side effects are:

  • Tardive dyskinesia (disabling movement disorder)
  • Sleep disorder
  • Apathy, loss of concentration
  • Abnormal vision
  • Hypotension
  • Skin rash
  • Leukocytosis (an increased number of white blood cells)
  • Rise in transaminases
  • Hyperglycemia

Gene or region studied

  • 7q21.3
  • 4q32.2
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