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Paracetamol efficacy in migraine and intense headaches

Paracetamol, also called acetaminophen, is a drug with analgesic and antipyretic properties used primarily to treat fever, and mild to moderate pain, including headache. Paracetamol is sometimes used as the first treatment to manage migraines and severe headaches in individuals who cannot tolerate or do not respond to NSAIDs. If paracetamol does not work, other more specific medications are prescribed for the treatment of migraines and severe headaches (such as triptans and ergotamines to treat the attacks, or preventive medications).

ACTION MECHANISM

Paracetamol inhibits the synthesis of prostaglandins in the central nervous system and blocks the generation of the pain impulse at the peripheral level. In addition, it acts on the hypothalamic temperature regulating center to exert its antipyretic effect.

CONTRAINDICATIONS

- Paracetamol is contraindicated in those individuals who present hypersensitivity to paracetamol or its prodrug, propacetamol hydrochloride.

- Those individuals with severe hepatocellular insufficiency and/or viral hepatitis.

- The rectal form of paracetamol is contraindicated in individuals with a recent history of rectitis, anitis or rectal bleeding.

- Extreme precautions should be taken in the use of paracetamol in individuals with liver and/or kidney failure.

SIDE EFFECTS

Rare: malaise, increased transaminase level, hypotension, hepatotoxicity, skin rash, hematological abnormalities, hypoglycemia, sterile pyuria.

 BRAND NAMES:

- Acecat®

- Alador®

- Antidol®

- Apiredol®

- Apiretal®

- Efferalgan®

- Tylenol®

- Etc.

 Paracetamol indicated for migraine processes or intense headaches:

- Excedrin Migraine®

- Other combinations with caffeine, etc.

Gene or region studied

  • UGT1A
  • SULT1A1
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